Crystallization (Comment) | Organism |
---|---|
ligand-free, binary and ternary complex structures with phosphate ions and dUMP | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A191K | inactive. Mutant has large areas of hydrophobic region exposed to solvent and exposes the hydrophobic beta-sheets in the dimer interface | Homo sapiens |
M190K | inactive. Mutant has large areas of hydrophobic region exposed to solvent and exposes the hydrophobic beta-sheets in the dimer interface | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
nolatrexed | upon binding, the two insert regions in thymidylate synthase, the functions of which are unclear, undergo positional shifts toward the catalytic center | Homo sapiens | |
raltitrexed | upon binding, the two insert regions in thymidylate synthase, the functions of which are unclear, undergo positional shifts toward the catalytic center | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P04818 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
TYMS | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | two insert regions in thymidylate synthase, the functions of which are unclear, are involved in the conformational transition between the active and inactive state. A cavity in the dimer interface could serve as an allosteric site to regulate the conformational switching between the active and inactive states | Homo sapiens |